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The alleged shooter reportedly yelled "all Jews must die" before opening fire on the Tree of Life Synagogue in Pittsburgh's Squirrel Hill neighborhood Saturday.
Pepe was originally created in honor of Free Comic Book Day.
The Anti-Defamation League confirmed at least 12 separate threats were phoned to Jewish institutions in the U.S. on Monday.
((())), the "echo" symbol used to identify and target Jews, has been added to the Anti-Defamation League's "Hate on Display" list.
The Anti-Defamation League has told the gun lobby to stop misusing the Holocaust to advance their argument.